Ville Wallenius, Kirurgi, Avd. Gastrokirurgisk forskning och utbildning, Sahlgrenska Universitetssjukhuset,

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Article - Review (2)

1. The therapeutic potential of interleukin-6 in treating obesity.

   Wallenius Kristina, Jansson John-Olov, Wallenius Ville.

   Expert Opin Biol Ther 2003:3(7):1061-70.

   [Links: PMID: 14519071 | DOI länk][Source: PubMed®]

   Web of Science® citations 17
2. On the site and mechanism of action of the anti-obesity effects of interleukin-6.

   Jansson John-Olov, Wallenius Kristina, Wernstedt Ingrid, Ohlsson Claes, Dickson Suzanne L, Wallenius Ville.

   Growth Horm IGF Res. 2003:13:S28-32.

   [Links: PMID: 12914723][Source: PubMed®]

   Web of Science® citations 13

Article - Peer reviewed scientific (24)

1. Central nervous system lipocalin-type prostaglandin D2-synthase (L-PGDS) is correlated with orexigenic neuropeptides, visceral adiposity and markers of the hypothalamic-pituitary-adrenal axis in obese humans.

   Elias Erik, Benrick Anna, Behre Carl Johan, Ekman Rolf, Zetterberg Henrik, Stenlöf Kaj, Wallenius Ville.

   Journal of neuroendocrinology 2011

   [Links: PMID: 21438929 | DOI länk][Source: PubMed®]

   Web of Science® citations 0
2. The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old Swedish men.

   Wallenius V, Elias E, Bergstrom G M L, Zetterberg H, Behre C J.

   Exp Clin Endocrinol Diabetes 2011:119(2):75-80.

   [Links: PMID: 21104585 | DOI länk][Source: PubMed®]
3. Erythrocyte sodium-lithium countertransport activity is inversely correlated to adiponectin, retinol binding protein 4 and body height.

   Elias Erik, Wallenius Ville, Herlitz Hans, Bergström Göran M L, Olson Fredrik J, Behre Carl J.

   Scand J Clin Lab Invest. 2010:70(7):487-91.

   [Links: PMID: 20849357 | DOI länk][Source: PubMed®]

   Web of Science® citations 0
4. Erythrocyte sodium-lithium countertransport activity is inversely correlated to adiponectin, retinol binding protein 4 and body height.

   Elias Erik, Wallenius Ville, Herlitz Hans, Bergström Göran M L, Olson Fredrik J, Behre Carl J.

   Scandinavian journal of clinical and laboratory investigation 2010

   [Links: PMID: 20849357 | DOI länk][Source: PubMed®]

   Web of Science® citations 0
5. Mature-onset obesity in interleukin-1 receptor I knockout mice.

   García Maria C, Wernstedt Ingrid, Berndtsson Anna, Enge Maria, Bell Michal, Hultgren Olof, Horn Michael, Ahrén Bo, Enerback Sven, Ohlsson Claes, Wallenius Ville, Jansson John-Olov.

   Diabetes 2006:55(5):1205-13.

   [Links: PMID: 16644674][Source: PubMed®]

   Web of Science® citations 53
6. Interleukin-1 system gene polymorphisms are associated with fat mass in young men.

   Strandberg Louise, Lorentzon Mattias, Hellqvist Asa, Nilsson Staffan, Wallenius Ville, Ohlsson Claes, Jansson John-Olov.

   J Clin Endocrinol Metab. 2006:91(7):2749-54.

   [Links: PMID: 16636119 | DOI länk][Source: PubMed®]

   Web of Science® citations 20
7. Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-)) mice.

   Wernstedt I, Olsson B, Jernås M, Paglialunga S, Carlsson L M S, Smith U, Cianflone K, Wallenius K, Wallenius V.

   Endocrinology 2006:147(6):2690-5.

   [Links: PMID: 16513824 | DOI länk][Source: PubMed®]

   Web of Science® citations 10
8. Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice.

   Wernstedt Ingrid, Edgley Amanda, Berndtsson Anna, Fäldt Jenny, Bergström Göran, Wallenius Ville, Jansson John-Olov.

   Am J Physiol Regul Integr Comp Physiol. 2006:291(3):R551-7.

   [Links: PMID: 16455769 | DOI länk][Source: PubMed®]

   Web of Science® citations 17
9. Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells.

   Fernández-Veledo Sonia, Valdés Raquel, Wallenius Ville, Casado F Javier, Pastor-Anglada Marçal.

   J Hepatol. 2004:41(4):538-44.

   [Links: PMID: 15464233 | DOI länk][Source: PubMed®]

   Web of Science® citations 16
10. Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice.

    Persson Linda, Borén Jan, Robertson Anna-Karin L, Wallenius Ville, Hansson Göran K, Pekna Marcela.

    Arterioscler Thromb Vasc Biol. 2004:24(6):1062-7.

    [Links: PMID: 15059809 | DOI länk][Source: PubMed®]

    Web of Science® citations 33
11. Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects.

    Stenlöf Kaj, Wernstedt Ingrid, Fjällman Ted, Wallenius Ville, Wallenius Kristina, Jansson John-Olov.

    J Clin Endocrinol Metab. 2003:88(9):4379-83.

    [Links: PMID: 12970313][Source: PubMed®]

    Web of Science® citations 39
12. Intracerebroventricular interleukin-6 treatment decreases body fat in rats.

    Wallenius Kristina, Wallenius Ville, Sunter David, Dickson Suzanne L, Jansson John-Olov.

    Biochem Biophys Res Commun. 2002:293(1):560-5.

    [Links: PMID: 12054638 | DOI länk][Source: PubMed®]

    Web of Science® citations 84
13. Interleukin-6-deficient mice develop mature-onset obesity.

    Wallenius Ville, Wallenius Kristina, Ahrén Bo, Rudling Mats, Carlsten Hans, Dickson Suzanne L, Ohlsson Claes, Jansson John-Olov.

    Nat Med. 2002:8(1):75-9.

    [Links: PMID: 11786910 | DOI länk][Source: PubMed®]

    Web of Science® citations 457
14. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization.

    Walentinsson A, Helou K, Wallenius V, Hedrich H J, Szpirer C, Levan G.

    Cancer Res. 2001:61(22):8263-73.

    [Links: PMID: 11719459][Source: PubMed®]

    Web of Science® citations 11
15. Liver-derived IGF-I regulates GH secretion at the pituitary level in mice.

    Wallenius K, Sjögren K, Peng X D, Park S, Wallenius V, Liu J L, Umaerus M, Wennbo H, Isaksson O, Frohman L, Kineman R, Ohlsson C, Jansson J O.

    Endocrinology 2001:142(11):4762-70.

    [Links: PMID: 11606442][Source: PubMed®]

    Web of Science® citations 45
16. Retarded liver growth in interleukin-6-deficient and tumor necrosis factor receptor-1-deficient mice.

    Wallenius V, Wallenius K, Hisaoka M, Sandstedt J, Ohlsson C, Kopf M, Jansson J O.

    Endocrinology 2001:142(7):2953-60.

    [Links: PMID: 11416016][Source: PubMed®]

    Web of Science® citations 14
17. Normal pharmacologically-induced, but decreased regenerative liver growth in interleukin-6-deficient (IL-6(-/-)) mice.

    Wallenius V, Wallenius K, Jansson J O.

    J Hepatol. 2000:33(6):967-74.

    [Links: PMID: 11131460][Source: PubMed®]

    Web of Science® citations 20
18. Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors.

    Wallenius V, Hisaoka M, Helou K, Levan G, Mandahl N, Meis-Kindblom J M, Kindblom L G, Jansson J O.

    Am J Pathol. 2000:156(3):821-9.

    [Links: PMID: 10702398][Source: PubMed®]

    Web of Science® citations 47
19. Hepatocyte-stimulated expression of hepatocyte growth factor (HGF) in cultured rat hepatic stellate cells.

    Skrtic S, Wallenius V, Ekberg S, Brenzel A, Gressner A M, Jansson J O.

    J Hepatol. 1999:30(1):115-24.

    [Links: PMID: 9927158][Source: PubMed®]

    Web of Science® citations 20
20. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice.

    Sjögren K, Liu J L, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Törnell J, Isaksson O G, Jansson J O, Ohlsson C.

    Proc Natl Acad Sci U.S.A. 1999:96(12):7088-92.

    [Links: PMID: 10359843][Source: PubMed®]

    Web of Science® citations 464
21. Amplification and overexpression of the hepatocyte growth factor receptor (HGFR/MET) in rat DMBA sarcomas.

    Helou K, Wallenius V, Qiu Y, Ohman F, Ståhl F, Klinga-Levan K, Kindblom L G, Mandahl N, Jansson J O, Levan G.

    Oncogene 1999:18(21):3226-34.

    [Links: PMID: 10359528 | DOI länk][Source: PubMed®]

    Web of Science® citations 15
22. Changes in expression of CCAAT/enhancer binding protein alpha (C/EBP alpha) and C/EBP beta in rat liver after partial hepatectomy but not after treatment with cyproterone acetate.

    Skrtic S, Ekberg S, Wallenius V, Enerbäck S, Hedin L, Jansson J O.

    J Hepatol. 1997:27(5):903-11.

    [Links: PMID: 9382979][Source: PubMed®]

    Web of Science® citations 15
23. Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells.

    Skrtic S, Wallenius V, Ekberg S, Brenzel A, Gressner A M, Jansson J O.

    Endocrinology 1997:138(11):4683-9.

    [Links: PMID: 9348194][Source: PubMed®]

    Web of Science® citations 34
24. Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA.

    Wallenius V R, Rawet H, Skrtic S, Helou K, Qiu Y, Levan G, Ekberg S, Carlsson B, Isaksson O G, Nakamura T, Jansson J O.

    Mamm Genome 1997:8(9):661-7.

    [Links: PMID: 9271668][Source: PubMed®]

    Web of Science® citations 14

Article - Other scientific (1)

1. Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis.

   Jansson John-Olov, Wallenius Ville.

   J Appl Physiol. 2007:102(2):821; author reply 82.

   [Links: PMID: 17323464][Source: PubMed®]

Nedan visas publikationer tillfälligt inlagda som text innan de konverteras till publikationsdatabasen.

Vetenskapliga publikationer

Garcia MC, Wernstedt I, Berndtsson A, Enge M, Bell M, Hultgren O, Horn M, Ahren B, Enerback S, Ohlsson C, Wallenius V, Jansson JO.
Mature-onset obesity in interleukin-1 receptor I knockout mice. Diabetes. 2006 May;55(5):1205-13.

Strandberg L, Lorentzon M, Hellqvist A, Nilsson S, Wallenius V, Ohlsson C, Jansson JO.
Interleukin-1 system gene polymorphisms are associated with fat mass in young men.J Clin Endocrinol Metab. 2006 Jul;91(7):2749-54.

Wernstedt I, Olsson B, Jernas M, Paglialunga S, Carlsson LM, Smith U, Cianflone K, Wallenius K, Wallenius V.
Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-)) mice.Endocrinology. 2006 Jun;147(6):2690-5.

Wernstedt I, Edgley A, Berndtsson A, Faldt J, Bergstrom G, Wallenius V, Jansson JO.
Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice.Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R551-7.

Fernandez-Veledo S, Valdes R, Wallenius V, Casado FJ, Pastor-Anglada M.
Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells. J Hepatol. 2004 Oct;41(4):538-44.

Persson L, Boren J, Robertson AK, Wallenius V, Hansson GK, Pekna M.
Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice.
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1062-7.

Stenlof K, Wernstedt I, Fjallman T, Wallenius V, Wallenius K, Jansson JO.
Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects.
J Clin Endocrinol Metab. 2003 Sep;88(9):4379-83.

Wallenius K, Wallenius V, Sunter D, Dickson SL, Jansson JO.
Intracerebroventricular interleukin-6 treatment decreases body fat in rats.
Biochem Biophys Res Commun. 2002 Apr 26;293(1):560-5.

Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, Jansson JO.
Interleukin-6-deficient mice develop mature-onset obesity.
Nat Med. 2002 Jan;8(1):75-9.

Walentinsson A, Helou K, Wallenius V, Hedrich HJ, Szpirer C, Levan G.
Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization.
Cancer Res. 2001 Nov 15;61(22):8263-73.

Wallenius K, Sjogren K, Peng XD, Park S, Wallenius V, Liu JL, Umaerus M, Wennbo H, Isaksson O, Frohman L, Kineman R, Ohlsson C, Jansson JO.
Liver-derived IGF-I regulates GH secretion at the pituitary level in mice.
Endocrinology. 2001 Nov;142(11):4762-70.

Wallenius V, Wallenius K, Hisaoka M, Sandstedt J, Ohlsson C, Kopf M, Jansson JO.
Retarded liver growth in interleukin-6-deficient and tumor necrosis factor receptor-1-deficient mice.
Endocrinology. 2001 Jul;142(7):2953-60.

Wallenius V, Wallenius K, Jansson JO.
Normal pharmacologically-induced, but decreased regenerative liver growth in interleukin-6-deficient (IL-6(-/-)) mice.
J Hepatol. 2000 Dec;33(6):967-74.

Wallenius V, Hisaoka M, Helou K, Levan G, Mandahl N, Meis-Kindblom JM, Kindblom LG, Jansson JO.
Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors.
Am J Pathol. 2000 Mar;156(3):821-9.

Sjogren K, Liu JL, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Tornell J, Isaksson OG, Jansson JO, Ohlsson C.
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice.
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7088-92.

Helou K, Wallenius V, Qiu Y, Ohman F, Stahl F, Klinga-Levan K, Kindblom LG, Mandahl N, Jansson JO, Levan G.
Amplification and overexpression of the hepatocyte growth factor receptor (HGFR/MET) in rat DMBA sarcomas.
Oncogene. 1999 May 27;18(21):3226-34.

Skrtic S, Wallenius V, Ekberg S, Brenzel A, Gressner AM, Jansson JO.
Hepatocyte-stimulated expression of hepatocyte growth factor (HGF) in cultured rat hepatic stellate cells.
J Hepatol. 1999 Jan;30(1):115-24.

Skrtic S, Ekberg S, Wallenius V, Enerback S, Hedin L, Jansson JO.
Changes in expression of CCAAT/enhancer binding protein alpha (C/EBP alpha) and C/EBP beta in rat liver after partial hepatectomy but not after treatment with cyproterone acetate.
J Hepatol. 1997 Nov;27(5):903-11.

Skrtic S, Wallenius V, Ekberg S, Brenzel A, Gressner AM, Jansson JO.
Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells.
Endocrinology. 1997 Nov;138(11):4683-9.

Wallenius V, Rawet H, Skrtic S, Helou K, Qiu Y, Levan G, Ekberg S, Carlsson B, Isaksson OG, Nakamura T, Jansson JO.
Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA.
Mamm Genome. 1997 Sep;8(9):661-7.

Övriga publikationer

Jansson JO, Wallenius V.
Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis.J Appl Physiol. 2007 Feb;102(2):821.

Wallenius K, Jansson JO, Wallenius V.
The therapeutic potential of interleukin-6 in treating obesity.
Expert Opin Biol Ther. 2003 Oct;3(7):1061-70.

Jansson JO, Wallenius K, Wernstedt I, Ohlsson C, Dickson SL, Wallenius V.
On the site and mechanism of action of the anti-obesity effects of interleukin-6.
Growth Horm IGF Res. 2003 Aug;13 Suppl A:S28-32.

Praktisk tentamen av medicinkandidater kursen i kirurgi höstterminen 2006. Sahlgrenska Univ sjukhuset.

Grupphandledning och dugga av läkarkandidater på kirurgterminen hösten 2006, Sahlgrenska Univ sjukhuset.

Föreläsningar och praktiska demonstrationer för medicinstudenter i Obesitas inom ramen för ”Electives in physiology” hösten 2006, våren 2007, våren 2008. Inst Neurovetenskap och fysiologi, Göteborgs Universitet.

Föreläsningar om obesitas på vidareutbildningskurs för sjuksköterskor i Endokrinologi våren 2006, Vårdhögskolan Göteborg.

Våren 2005 fullgjort docentutbildningskurs ”Högskolepedagogisk introduktionskurs”, samt kurs i ”Vetenskaplig handledning”.

Seminariehandledare för medicinstudenter termin 4 i endokrin immunologi HT 2004.

Handledare för gruppundervisning och seminarieuppgift i Biomedicinsk cellbiologi i ämnet ”Cell-cell signalering, hormoner och receptorer”, VT 1996.

Föreläsning för Biomedicinska analytikerutbildning, 1996.
”Odling av primärisolerade hepatocyter”.

Amanuens vid Inst. för Fysiologi och Farmakologi, Avd. för Endokrinologi, Med fak, Göteborgs Universitet, HT 1991-VT 1994, innefattande undervisning, seminarier, laborationer och muntliga prov för medicinstudenter.

Svenska Endokrinologföreningens pris "Endocrina" 2002.

Postdoktorand 2000 03 01 - 2002 01 31 inom sameuropeiskt forskningprojekt Framework 5, ”Quality of Life and Management of Living Resources Programme” (kontraktsnummer QRLT-1999-02038), med Postdocvistelse hos Dr. Suzanne Dickson, Dept. Physiology, University of Cambridge.

| uppdaterad: 2011-09-19 av Ville Wallenius |