Niklas Andersson, Livmedelsvetenskap, Institutionen för kemi- och bioteknik, Chalmers Tekniska Högskola

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Article - Peer reviewed scientific (28)

1. Gastrin effects on isolated rat enterochromaffin-like cells following long-term hypergastrinaemia in vivo.
   Andersson N, Rhedin M, Peteri-Brunbäck B, Andersson K, Cabero J L.
   Biochim Biophys Acta 1999:1451(2):297-304.[Source: PubMed®]
   [Links: PMID: 10556584]
2. Repeated in vivo determinations of bone mineral density during parathyroid hormone treatment in ovariectomized mice.
   Andersson N, Lindberg M K, Ohlsson C, Andersson K, Ryberg B.
   J Endocrinol. 2001:170(3):529-37.[Source: PubMed®]
   [Links: PMID: 11524233]
3. Comparison of osteopenia after gastrectomy, ovariectomy and prednisolone treatment in the young female rat.
   Surve V V, Andersson N, Lehto-Axtelius D, Håkanson R.
   Acta orthopaedica Scandinavica 2001:72(5):525-32.[Source: PubMed®]
   [Links: PMID: 11728082 | DOI länk]
4. Does combined gastrectomy and ovariectomy induce greater osteopenia in young female rats than gastrectomy alone?
   Surve V V, Andersson N, Alatalo S, Lehto-Axtelius D, Halleen J, Väänänen K, Håkanson R.
   Calcif Tissue Int. 2001:69(5):274-80.[Source: PubMed®]
   [Links: PMID: 11768197]
5. Estrogen receptor specificity for the effects of estrogen in ovariectomized mice.
   Lindberg M K, Weihua Z, Andersson N, Movérare S, Gao H, Vidal O, Erlandsson M, Windahl S, Andersson G, Lubahn D B, Carlsten H, Dahlman-Wright K, Gustafsson J-A, Ohlsson C.
   J Endocrinol. 2002:174(2):167-78.[Source: PubMed®]
   [Links: PMID: 12176656]
6. Molecular characterization of mouse gastric epithelial progenitor cells.
   Mills Jason C, Andersson Niklas, Hong Chieu V, Stappenbeck Thaddeus S, Gordon Jeffrey I.
   Proc Natl Acad Sci U.S.A. 2002:99(23):14819-24.[Source: PubMed®]
   [Links: PMID: 12409607 | DOI länk]
7. Drug-induced prevention of gastrectomy- and ovariectomy-induced osteopaenia in the young female rat.
   Andersson N, Surve V V, Lehto-Axtelius D, Ohlsson C, Håkanson R, Andersson K, Ryberg B.
   J Endocrinol. 2002:175(3):695-703.[Source: PubMed®]
   [Links: PMID: 12475380]
8. Molecular characterization of mouse gastric zymogenic cells.
   Mills Jason C, Andersson Niklas, Stappenbeck Thaddeus S, Chen Christopher C M, Gordon Jeffrey I.
   J Biol Chem. 2003:278(46):46138-45.[Source: PubMed®]
   [Links: PMID: 12963718 | DOI länk]
9. Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice.
   Movérare Sofia, Venken Katrien, Eriksson Anna-Lena, Andersson Niklas, Skrtic Stanko, Wergedal Jon, Mohan Subburaman, Salmon Phil, Bouillon Roger, Gustafsson Jan-Ake, Vanderschueren Dirk, Ohlsson Claes.
   Proc Natl Acad Sci U.S.A. 2003:100(23):13573-8.[Source: PubMed®]
   [Links: PMID: 14573701 | DOI länk]
10. Estren is a selective estrogen receptor modulator with transcriptional activity.
    Movérare Sofia, Dahllund Johanna, Andersson Niklas, Islander Ulrika, Carlsten Hans, Gustafsson Jan-Ake, Nilsson Stefan, Ohlsson Claes.
    Mol Pharmacol. 2003:64(6):1428-33.[Source: PubMed®]
    [Links: PMID: 14645673 | DOI länk]
11. Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice.
    Chagin A S, Lindberg M K, Andersson N, Moverare S, Gustafsson J A, Sävendahl L, Ohlsson C.
    J Bone Miner Res. 2004:19(1):72-7.[Source: PubMed®]
    [Links: PMID: 14753739]
12. Pharmacological treatment of osteopenia induced by gastrectomy or ovariectomy in young female rats.
    Andersson Niklas, Surve Vikas V, Lehto-Axtelius Daisy, Andersson Kjell, Ryberg Birgitta, Ohlsson Claes, Håkanson Rolf.
    Acta orthopaedica Scandinavica 2004:75(2):201-9.[Source: PubMed®]
    [Links: PMID: 15180236 | DOI länk]
13. A gene expression fingerprint of mouse stomach ECL cells.
    Andersson Niklas, Skrtic Sofia Movérare, Håkanson Rolf, Ohlsson Claes.
    Biochem Biophys Res Commun. 2005:332(2):404-10.[Source: PubMed®]
    [Links: PMID: 15896709 | DOI länk]
14. Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study.
    Lorentzon Mattias, Swanson Charlotte, Andersson Niklas, Mellström Dan, Ohlsson Claes.
    J Bone Miner Res. 2005:20(8):1334-41.[Source: PubMed®]
    [Links: PMID: 16007330 | DOI länk]
15. Investigation of central versus peripheral effects of estradiol in ovariectomized mice.
    Andersson N, Islander U, Egecioglu E, Löf Elin, Lindberg MK, Carlsten H, Ohlsson C, Lindberg Marie K, Carlsten Hans, Ohlsson Claes.
    J Endocrinol. 2005:187(2):303-9.[Source: PubMed®]
    [Links: PMID: 16293778 | DOI länk]
16. Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss.
    Lindberg M K, Svensson J, Venken K, Chavoshi T, Andersson N, Movérare Skrtic S, Isaksson O, Vanderschueren D, Carlsten H, Ohlsson C.
    Bone 2006:38(1):85-92.[Source: PubMed®]
    [Links: PMID: 16257281 | DOI länk]
17. Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice.
    Movérare-Skrtic Sofia, Venken Katrien, Andersson Niklas, Lindberg Marie K, Svensson Johan, Swanson Charlotte, Vanderschueren Dirk, Oscarsson Jan, Gustafsson Jan-Ake, Ohlsson Claes.
    Obesity (Silver Spring) 2006:14(4):662-72.[Source: PubMed®]
    [Links: PMID: 16741268 | DOI länk]
18. SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density.
    Eriksson Anna-Lena, Lorentzon Mattias, Mellström Dan, Vandenput Lisbeth, Swanson Charlotte, Andersson Niklas, Hammond Geoffery, Jakobsson Jenny, Rane Anders, Orwoll Eric, Ljungren Osten, Johnell Olov, Labrie Fernand, Windahl Sara, Ohlsson Claes.
    J Clin Endocrinol Metab. 2006:91(12):5029-37.[Source: PubMed®]
    [Links: PMID: 16926255 | DOI länk]
19. Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo.
    Shao Ruijin, Weijdegård Birgitta, Fernandez-Rodriguez Julia, Egecioglu Emil, Zhu Changlian, Andersson Niklas, Thurin-Kjellberg Ann, Bergh Christina, Billig Håkan.
    Am J Physiol Endocrinol Metab. 2007:293(1):E147-58.[Source: PubMed®]
    [Links: PMID: 17374697 | DOI länk]
20. Identification of target cells for the genomic effects of estrogens in bone.
    Windahl S H, Lagerquist M K, Andersson N, Jochems C, Kallkopf A, Håkansson C, Inzunza J, Gustafsson J-A, van der Saag P T, Carlsten H, Pettersson K, Ohlsson C.
    Endocrinology 2007:148(12):5688-95.[Source: PubMed®]
    [Links: PMID: 17761761 | DOI länk]
21. Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors.
    Shao Ruijin, Egecioglu Emil, Weijdegård Birgitta, Kopchick John J, Fernandez-Rodriguez Julia, Andersson Niklas, Billig Håkan.
    Am J Physiol Endocrinol Metab. 2007:293(5):E1430-42.[Source: PubMed®]
    [Links: PMID: 17848632 | DOI länk]
22. Liver-derived IGF-I enhances the androgenic response in prostate.
    Svensson Johan, Kindblom Jon, Shao Ruijin, Movérare-Skrtic Sofia, Lagerquist Marie, Andersson Niklas, Sjögren Klara, Venken Katrien, Vanderschueren Dirk, Jansson John-Olov, Isaksson Olle, Ohlsson Claes.
    J Endocrinol. 2008[Source: PubMed®]
    [Links: PMID: 18827067 | DOI länk]
23. Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
    Mårtensson Ulrika E A, Salehi S Albert, Windahl Sara, Gomez Maria F, Swärd Karl, Daszkiewicz-Nilsson Joanna, Wendt Anna, Andersson Niklas, Hellstrand Per, Grände Per-Olof, Owman Christer, Rosen Clifford J, Adamo Martin L, Lundquist Ingmar, Rorsman Patrik, Nilsson Bengt-Olof, Ohlsson Claes, Olde Björn, Leeb-Lundberg L M Fredrik.
    Endocrinology 2009:150(2):687-98.[Source: PubMed®]
    [Links: PMID: 18845638 | DOI länk]
24. The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice.
    Windahl S H, Andersson N, Chagin A S, Mårtensson U E A, Carlsten H, Olde B, Swanson C, Movérare-Skrtic S, Sävendahl L, Lagerquist M K, Leeb-Lundberg L M F, Ohlsson C.
    Am J Physiol Endocrinol Metab. 2009:296(3):E490-6.[Source: PubMed®]
    [Links: PMID: 19088255 | DOI länk]
25. Elevated Aromatase Expression in Osteoblasts Leads to Increased Bone Mass without Systemic Adverse Effects.
    Sjögren Klara, Lagerquist Marie, Moverare-Skrtic Sofia, Andersson Niklas, Windahl Sara H, Swanson Charlotte, Mohan Subburaman, Poutanen Matti, Ohlsson Claes.
    J Bone Miner Res. 2009[Source: PubMed®]
    [Links: PMID: 19257817 | DOI länk]
26. Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men.
    Andersson N, Strandberg L, Nilsson S, Ljungren O, Karlsson M K, Mellström D, Lorentzon M, Ohlsson C, Jansson J-O.
    International journal of obesity (2005) 2009:33(5)[Source: PubMed®]
    [Links: PMID: 19290009 | DOI länk]
27. Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
    Egecioglu Emil, Ploj Karolina, Xu Xiufeng, Bjursell Mikael, Salomé Nicolas, Andersson Niklas, Ohlsson Claes, Taube Magdalena, Hansson Caroline, Bohlooly-Y Mohammad, Morgan David G A, Dickson Suzanne L.
    Am J Physiol Endocrinol Metab. 2009:297(3):E708-16.[Source: PubMed®]
    [Links: PMID: 19584200 | DOI länk]
28. Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis.
    Strandberg Louise, Verdrengh Margareta, Enge Maria, Andersson Niklas, Amu Sylvie, Onnheim Karin, Benrick Anna, Brisslert Mikael, Bylund Johan, Bokarewa Maria, Nilsson Staffan, Jansson John-Olov.
    PLoS ONE 2009:4(10):e7605.[Source: PubMed®]
    [Links: PMID: 19865485 | DOI länk]

Manuskript ännu ej accepterade för publikation

Arbetsgivare	Anställningsgrad		Började	Slutade
Företag - Läkemedel etc - AstraZeneca - Mölndal, Göteborg		100%	1995	1997
Statligt - Universitet - Lunds Universitet - Med. fak., Inst för experimentell medicinsk vetenskap		100%	1997	2002
Statligt - Universitet - Göteborgs universitet - Sahlgrenska akademin - Institutionen för medicin, avdelningen för invärtesmedicin [2006 - ]		100%	2002	2007
Statligt - Universitet - Göteborgs universitet - Sahlgrenska akademin - Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi [2006 - ]		100%	2007	2009
Statligt - Högskolor - Chalmers tekniska högskola - Institutionen Kemi- och bioteknik		100%	2009

Invited Speaker

1.STRONG[Andersson N], Windahl MK, Sjögren K, Lindberg MK, Swanson C, Movérare Skrtic S & Ohlsson C. 5α-Reductase Type 1 Inactivated Male Mice Have Reduced Trabecular and Cortical Bone Mass. Journal of Bone and Mineral Research 2006;STRONG[21]:1017. (28th Annual Meeting of the American Society for Bone and Mineral Research, Philadelphia, Pennsylvania, USA)

2.STRONG[Andersson N], Lindberg MK, Movérare S, Svensson J, Chavoshi T, Venken K, Vanderschueren D, Carlsten H & Ohlsson C. Liver-derived insulin-like growth factor i is permissive for ovariectomy-induced bone loss. Journal of Bone and Mineral Research 2004;STRONG[19]:S43-S43. (26th Annual Meeting of the American Society for Bone and Mineral Research, Seattle, Washington, USA)

3.STRONG[Andersson N], Eriksson AL, Lorentzon M, Mellström D & Ohlsson C. The catechol-O-methyltransferase val158met polymorphism is associated with bone mineral density in young adult men. (Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis, Bethesda, Maryland, USA, May 24-25 2004)

4.STRONG[Andersson N], Surve VV, Lehto-Axtelius D, Ohlsson C & Håkanson R. Prevention of bone loss following gastrectomy or ovariectomy in the rat. Acta Orthopaedica Scandinavica 1999;STRONG[70],Suppl.287: (3rd Baltic Bone & Cartilage Conference, Ronneby, Sweden. August 26-29 1999)

Curriculum Vitae

Nikas Andersson
Fässbergsgatan 20
SE-431 69 Mölndal, Sweden
Telephone: +46-31-414122
E-mail: nikander@chalmers.se

Born: March 7, 1970, Järfälla, Sweden.

Professional preparation

2002-2007Postdoctoral Research Associate at the Division of Endocrinology, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden.

2001-2002Predoctoral Research Fellowship at the Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, Missouri, USA.

1998-2002Doctor of Philosophy in Pharmacology
Thesis Title: “Pharmacological Modulation of Skeletal Homeostasis”
Advisor: Professor Rolf Håkanson, Department of Pharmacology, Institute of Physiological Sciences, Lund University, Lund, Sweden. My PhD project was part of an academic-industrial collaboration between Lund University and AstraZeneca R&D, Mölndal, Sweden. I performed most of the in vivo work at AstraZeneca R&D as part of their osteoporosis research team.

1989-1995Master of Science in Chemistry, Linköping University, Linköping, Sweden.

1992-1993Exchange Student at University of Wisconsin at Madison, Madison Wisconsin, USA.

1991-1992Gruppbefäl (lower] non-commissioned officer), Compulsatory Military Service, Bergslagens Artilleriregemente, Kristinehamn, Sweden.

1986-1989Swedish High School, Rudbeckssskolan, Örebro, Sweden.

Current Positions

2009-Project Leader at Food Science – Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.

2007-2010Scientific Expert in the Animal Ethics Committee at the Administrative Court of Appeals (Kammarrätten), Gothenburg, Sweden.

Previous Positions

2007-2009Assistant Researcher (biträdande forskare) at the Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

2006Scientific Expert (deputy) in the Animal Ethics Committee at the Administrative Court of Appeals (Kammarrätten), Gothenburg, Sweden.

2002-2007Postdoctoral Research Associate at the Division of Endocrinology, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden.

2001-2002Predoctoral Research Fellow at the Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO, USA.

1998-2002Ph.D. Student, Department of Pharmacology, Institute of Physiological Sciences, Lund University, Lund, Sweden.

1995-1997Research Scientist, Gastrointestinal/Cardiovascular/Integrative Pharmacology & Cell Biology, AstraZeneca R&D, Mölndal, Sweden.

Awards and Honors

2006Recipient of the Young investigator award at the 28th annual meeting of the American Society for Bone and Mineral Research, Philadelphia, Pennsylvania, USA, September 15-19 2006. Abstract: 5α-Reductase Type 1 Inactivated Male Mice Have Reduced Trabecular and Cortical Bone Mass.

2004Recipient of the Young investigator award at the Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis, Bethesda, Maryland, USA, May 24-25 2004. Abstract: The catechol-O-methyltransferase val158met polymorphism is associated with bone mineral density in young adult men.

1992Recipient of a one-year scholarship from Linköping University, to University of Wisconsin at Madison, Madison, Wisconsin, USA.