ATTENTION - The document is under revision - ATTENTION

1. Översiktlig projektbeskrivning

Engelsk titel

The ovary and the uterus - from basic science to clinical application

Sammanfattning av projektet

Huvudsyftet med projektet är att genom experimentella, kliniska och epidemiologiska studier som berör ett antal vanliga kvinnosjukdomar öka vår kunskap för att förbättra diagnostik, behandling och omhändertagande efter behandling.
Frågeställningar:
1. Vilka LH inducerade gener är ovulations-specifika i det human ovariet och kan styrning av dess produkter användas för att stimulera ovulation vid infertilitet och inhibera i kontraceptionssyfte?
2. Vilken roll i OHSS patofysiologin har ett antal överuttryckta gener och hur kan denna kunskap användas vid prevention och behandling av OHSS?
3. Hur utvecklas PCOS hos kvinnor efter klimakteriet och finns förändrat genuttryck av patofysiologisk betydelse i PCOS ovarium?
4. Finns skillnader i hormonstatus, sexualitet och psykologiskt välbefinnande 8 år efter elektiv hysterektomi hos kvinnor som har genomgått oophorektomi i jämförelse med de som ej genomgått oophorektomi?
5. Kan steg-för-steg förfarande med djurexperiment bana vägen för klinisk introduktion av uterustransplantation?
6. Kan ovariekryopreservation optimeras för bevarande av fertilitet hos flickor och kvinnor som drabbas av cancer?
7. Hur är utfallet vid behandling av ovarialcancer i VGR och kan de kirurgiska behandlingarna utvecklas?
8. Kan ny teknik användas för att särskilja cervixcancer och dysplasi hos gravida och hur påverkas sexualitet och ovariefunktion efter kirurgisk behandling av cervixcancer.
9. Är laparoskopisk eller vaginal operation bäst vid operation av framfall efter hysterektomi?
The main goal is to improve diagnostics, treatment and postoperative care for a number of common female health issues by performing experimental, clinical and epidemiological studies.
Main topics:
1. Which LH-induced genes are ovulation-specific in the human ovary and can pertubations of these stimulate ovulation at anovulation or inhibit ovulation for contraception?
2. Which roles do a number of newly found genes, which are expressed in granulsa cells of OHSS patients, play in OHSS patophysiology?
3. What is the natural cause of PCOS after menopause women and is the expression pattern changed in PCOS ovary?
4. Are there differences in hormonal status, sexuality and psychological wellbeing 8 years after prophylactic oophorectomy in conjunction with hysterectomy as compared to only hysterectomy?
5. Can a step-by-step animal experimentation approach lead to clinical introduction of uterus transplantation?
6. Can ovarian cryopreservation be optimised for fertility preservation in young females with cancer?
7. How is the clinical outcome of treatment for ovarian cancer in western Sweden and can the surgery be improved?
8. Can new technology be used to discriminate dysplasia and microinvasive cervical cancer in pregnant women and how do sexuality and ovarian function change efter surgical treatment for cervical cancer?
9. Is laparoscopic or vaginal surgery best for correction of vaginal vault prolapse post hysterectomy?

Typ av projekt

Forskningsprojekt

MeSH-termer för att beskriva ämnesområdet

Inlagda MeSH-termer

Ovary

The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.

Uterus

The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.

Hysterectomy

Excision of the uterus.

Gynecologic Surgical Procedures

Surgery performed on the female genitalia.

Urogenital Surgical Procedures

Surgery performed on the urinary tract or its organs and on the male or female genitalia.

Surgical Procedures, Operative

Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.)

Cervix Uteri

The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.

Uterine Cervical Neoplasms

Tumors or cancer of the UTERINE CERVIX.

Neoplasms

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Urogenital Neoplasms

Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.

Genital Neoplasms, Female

Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).

Uterine Neoplasms

Tumors or cancer of the UTERUS.

Female Urogenital Diseases and Pregnancy Complications

Pathological processes of the female URINARY TRACT, the reproductive system (GENITALIA, FEMALE), and disorders related to PREGNANCY.

Female Urogenital Diseases

Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).

Genital Diseases, Female

Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).

Uterine Diseases

Pathological processes involving any part of the UTERUS.

Uterine Cervical Diseases

Pathological processes of the UTERINE CERVIX.

Ovarian Neoplasms

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Endocrine Gland Neoplasms

Tumors or cancer of the ENDOCRINE GLANDS.

Ovarian Diseases

Pathological processes of the OVARY.

Adnexal Diseases

Diseases of the uterine appendages (ADNEXA UTERI) including diseases involving the OVARY, the FALLOPIAN TUBES, and ligaments of the uterus (BROAD LIGAMENT; ROUND LIGAMENT).

Endocrine System Diseases

Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.

Gonadal Disorders

Pathological processes of the OVARIES or the TESTES.

Polycystic Ovary Syndrome

A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.

Ovarian Cysts

General term for CYSTS and cystic diseases of the OVARY.

Ovarian Hyperstimulation Syndrome

A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.

Transplantation

Transference of a tissue or organ, alive or dead, within an individual, between individuals of the same species, or between individuals of different species.

Ovariectomy

The surgical removal of one or both ovaries.

Castration

Surgical removal or artificial destruction of gonads.

Endocrine Surgical Procedures

Surgery performed on any endocrine gland.

Ovulation

The discharge of an OVUM from a rupturing follicle in the OVARY.

Reproduction

The total process by which organisms produce offspring. (Stedman, 25th ed)

Reproductive and Urinary Physiology

Physiology of the human and animal body, male or female, in the reproductive process and the physiology of the urinary tract.

Women

Human adult females as cultural, psychological, sociological, political, and economic entities.

Women's Health

The concept covering the physical and mental conditions of women.

Projektets delaktighet i utbildning

Avhandling
D-uppsats / Magisterexamen
C-uppsats / Kandidatexamen
ST-läkarutbildning
Annan utbildning
Ej del i utbildning

3. Processen och projektets redovisning

Pågående aktiviteter

Planering och förberedelse före datainsamling
Datainsamling pågår
Analys av insamlade data pågår
Författande av skriftlig redovisning / publikation pågår
En eller flera publikationer från projektet är publicerade
Slutfört och inget mer görs inom ramen för detta projekt

Projektstart (när planeringen påbörjas och börjar dokumenteras skriftligt)

2008-01-01

Datum för påbörjande av datainsamling

2008-01-01

Datum då projektet är slutrapporterat

2010-12-31

ATTENTION - The document is under revision - ATTENTION