Kliniska studier av osteoporos vid Systemisk lupus erythematosus (SLE).
Document number : 2378
Created by: Katarina Almehed, 2007-05-29
Last revised by: Katarina Almehed, 2010-08-20
Document created in: FoU i Sverige

Not updated

1. Översiktlig projektbeskrivning

Sammanfattning av projektet

Sammanfattning:
Systemisk Lupus Erythematosus (SLE) är en kronisk autoimmun reumatisk systemsjukdom som karaktäriseras av att det bildas autoantikroppar mot patientens egen vävnad. Detta ger upphov till inflammation i hud, leder, njurar, hjärta, kärl, lungor och centrala nervsystemet. SLE förekommer hos 50-80 per 100 000 invånare vilket betyder att ca 5000 personer i Sverige är drabbade. SLE är vanligare hos kvinnor än män. Hormonella faktorer påverkar insjuknandet i SLE och det är visat att kvinnligt könshormon kan försämra sjukdomen. Av denna anledning bör ej kvinnor med SLE behandlas med kvinnliga könshormoner efter klimakteriet. Behandlingen av aktiv SLE inkluderar immundämpande läkemedel som kortison och cellgifter. Dessa läkemedel kan ge biverkningar såsom ökad risk för infektioner samt osteoporos. Osteoporos är en sjukdom som karaktäriseras av nedsatt bentäthet och förändrad mikroarkitektur i skelettet, ledande till ökad risk för frakturer t.ex. kotkompressionsfrakturen. Möjliga orsaker till osteoporos vid SLE är bland annat kortisonmedicinering, tidigt klimakterium och hög sjukdomsaktivitet. Kvinnor med SLE är således speciellt utsatta för osteoporos därför att dessa kvinnors klimakterium inträffar tidigare samtidigt som de ej bör behandlas med hormonersättning.
Frågeställningar:
Är förekomsten av osteoporos förhöjd hos SLE patienter, både kvinnor och män, som kontrolleras på reumatologklinikerna i Västra Götaland?
Är frakturrisken i rygg, kotkompressioner, ökad jämfört med normalmaterial?
Vilka är de viktigaste riskfaktorerna för osteoporos hos våra SLE patienter?
Är resistin, en proinflammatorisk adipokin, associerad till bentäthet eller inflammation vid SLE?
Betydelse:
SLE patienter utgör en högriskgrupp för osteoporos och osteoporosrelaterade frakturer. Genom kartläggning av problemets omfattning och riskidentifiering hoppas vi kunna hjälpa denna patientgrupp med minskat lidande som följd men också minska samhälls- och vårdkostnader förenade med dessa frakturer. Förhoppningen är att på sikt bättre kunna förutsäga vilka patienter som har hög risk för frakturer och kunna ge förebyggande skelettuppbyggande behandling.

Typ av projekt

Forskningsprojekt

MeSH-termer för att beskriva ämnesområdet

Inlagda MeSH-termer

Absorptiometry, Photon: A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or AMERICUM 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Adult: A person having attained full growth or maturity. Adults are of 19 through 44 years of age.
Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Aged: A person 65 through 79 years of age. For a person older than 79 years, AGED, 80 AND OVER is available.
Aged, 80 and over: A person 80 years of age and older.
Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.
Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Blood Sedimentation: Measurement of rate of settling of erythrocytes in anticoagulated blood.
Body Mass Index: An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Creatinine
Female
Humans: Members of the species Homo sapiens.
Linear Models: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Middle Aged
Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Academic Dissertations: Works consisting of formal presentations made usually to fulfill requirements for an academic degree.