1. Översiktlig projektbeskrivning

Engelsk titel

Prevalence of arrhythmic death in consecutive post-myocardial infarction patients

Sammanfattning av projektet

Abstract

Background: A low ejection fraction after myocardial infarction is a criterion for prophylactic ICD implantation. We studied the prevalence of arrhythmic death in consecutive patients diagnosed with myocardial infarction in an environment with high activity in thrombolysis and percutaneous coronary interventions.

Patients: 583 patients were identified and myocardial infarction was confirmed. Seventy percent were males. All patients received any relevant care and/or investigations.

Results: The two-year all-cause mortality was 21.8%. Thirtyseven (6.3%) died <1 week, fourteen (2.4%) between 1 week and 1 month and another 75 patients (13%) between 1 month and 2 years. Eighteen of 37 patients had no echocardiography, while 7 had an EF<0.30; 7 had an EF 0.31-0.40 and 5 an EF >0.40. Nineteen of those who died between 1 month and 2 years had no echocardiography, 14 had EF <0.30, 18 an EF 0.31-0.40 and 24 an EF >0.41. In the patients who survived for >2 years, only 5% of patients had an EF <0.30, 12.2% had an EF 0.31-0.40 and 83.3% an EF >0.40A history of atrial fibrillation was present in 26%, 36%, and 28% of those who died <1 week, between 1 week and 1 month and between 1 month and 2 years, respectively, as compared with 8% in survivors at >2 years.

Conclusion: The all-cause mortality between one month -two years was 13%. An EF<0.30 was associated with a 25% of the mortality in that interval, as compared with 32% for an EF 0.31-0.40 and 43% for an EF>0.40

Typ av projekt

Forskningsprojekt

MeSH-termer för att beskriva ämnesområdet

Inlagda MeSH-termer

Academic Dissertations

Works consisting of formal presentations made usually to fulfill requirements for an academic degree.

Myocardial Infarction

NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

Cardiovascular Diseases

Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Risk Factors

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Health Care Evaluation Mechanisms

Methods and techniques used in evaluating the quality of health care, its planning, and delivery.

Mortality

All deaths reported in a given population.

Data Collection

Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.

Defibrillators, Implantable

Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.

Projektets delaktighet i utbildning

Avhandling
D-uppsats / Magisterexamen
C-uppsats / Kandidatexamen
ST-läkarutbildning
Annan utbildning
Ej del i utbildning

3. Processen och projektets redovisning

Pågående aktiviteter

Planering och förberedelse före datainsamling
Datainsamling pågår
Analys av insamlade data pågår
Författande av skriftlig redovisning / publikation pågår
En eller flera publikationer från projektet är publicerade
Slutfört och inget mer görs inom ramen för detta projekt

Projektstart (när planeringen påbörjas och börjar dokumenteras skriftligt)

2004-01-01

Datum för påbörjande av datainsamling

2001-08-01

Datum då projektet är slutrapporterat

2007-09-01

Publikationer från detta projekt

1. Presumed arrhythmic death in consecutive survivors of acute myocardial infarction--implications for primary implantable cardioverter defibrillator implantation.
   Holmgren Christina M, Nyström Britta M, Karlsson Thomas K, Herlitz Johan D, Edvardsson Nils G.
   Coron Artery Dis. 2009:20(2):155-62.[Source: PubMed®]
   [Links: PMID: 19238081 | DOI länk]

Tillämpning av resultat - tidsaspekt (projektledarens bedömning)

Resultaten kommer sannolikt att tillämpas inom 1 år från projektslut.

Tillämpning av resultat - genomslag (projektledarens bedömning)

Nationellt (i stor del av landet)

Tillämpning av resultat - beskrivning

Vi kommer att visa vilket utfall tillämpningen av dessa kriterier kommer att få i en konsekutiv population, vilket kommer att ge stöd för hur de bör användas i den kliniska vardagen. Detta kan vara av intresse inte minst för prioriteringen av kostsamma åtgärder inom hälso och sjukvården.